GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THYM | cis | rs10461617 | 1 | rs2548665 | chr5:56131805 | C5orf35 | chr5:56205103-56213010:+ | 0.74 | 8.92 | 3.44E-14 | Type 2 diabetes |
| THYM | cis | rs2564921 | 1 | rs2564921 | chr3:53125585 | RFT1 | chr3:53122503-53164470:- | 0.44 | 4.91 | 3.78E-6 | Height |
| THYM | cis | rs2564921 | 1 | rs2564940 | chr3:53107569 | RFT1 | chr3:53122503-53164470:- | -0.44 | -5 | 2.58E-6 | Height |
| THYM | cis | rs2294008 | 1 | rs2572910 | chr8:143770135 | PSCA | chr8:143761875-143764142:+ | 0.42 | 4.21 | 5.89E-5 | Gastric adenocarcinoma (histologically verified);Non-cardia gastric cancer;Gastric cancer;Duodenal ulcer;Bladder cancer |
| THYM | cis | rs2564921 | 1 | rs2581782 | chr3:53122257 | RFT1 | chr3:53122503-53164470:- | -0.44 | -4.93 | 3.42E-6 | Height |
| THYM | cis | rs2564921 | 1 | rs2581783 | chr3:53122258 | RFT1 | chr3:53122503-53164470:- | -0.44 | -4.93 | 3.42E-6 | Height |
| THYM | cis | rs2564921 | 1 | rs2581786 | chr3:53126143 | RFT1 | chr3:53122503-53164470:- | -0.44 | -4.91 | 3.78E-6 | Height |
| THYM | cis | rs2564921 | 1 | rs2581787 | chr3:53127677 | RFT1 | chr3:53122503-53164470:- | -0.42 | -4.59 | 1.35E-5 | Height |
| THYM | cis | rs2564921 | 1 | rs2581800 | chr3:53109352 | RFT1 | chr3:53122503-53164470:- | -0.4 | -4.44 | 2.41E-5 | Height |
| THYM | cis | rs2294008 | 1 | rs2585179 | chr8:143774193 | PSCA | chr8:143761875-143764142:+ | 0.42 | 4.21 | 5.86E-5 | Gastric adenocarcinoma (histologically verified);Non-cardia gastric cancer;Gastric cancer;Duodenal ulcer;Bladder cancer |
| THYM | cis | rs2251844 | 1 | rs2614811 | chr15:43913487 | ADAL | chr15:43622872-43646094:+ | -0.5 | -4.35 | 3.42E-5 | Tumor biomarkers |
| THYM | cis | rs9815354 | 1 | rs2625667 | chr3:41900951 | ULK4 | chr3:41288091-42003660:- | 1.02 | 11.47 | 1.22E-19 | Diastolic blood pressure |
| THYM | cis | rs9815354 | 1 | rs2625668 | chr3:41905930 | ULK4 | chr3:41288091-42003660:- | 1 | 11.02 | 1.12E-18 | Diastolic blood pressure |
| THYM | cis | rs10804591 | 1 | rs2625984 | chr3:129339101 | TMCC1 | chr3:129366637-129612403:- | -0.31 | -4.29 | 4.36E-5 | Waist-to-hip ratio adjusted for body mass index |
| THYM | cis | rs2629540 | 1 | rs2629540 | chr10:126426148 | METTL10 | chr10:126447406-126480439:- | 0.4 | 4.43 | 2.54E-5 | Cocaine dependence |